Copper deficiency impairs mitochondrial respiration, antioxidant defense, and vascular structural integrity, whereas copper overload triggers oxidative stress, inflammatory responses, and aberrant activation of cell death signaling
In a study by Cui et al., an analysis of 496 PCa patients from The Cancer Genome Atlas (TCGA) database revealed a correlation between increased AKR1C3 expression and advanced disease stages, as indicated by high T stage, N stage, and Gleason score values
[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Govic A., Nasser H., Levay E.A., Zelko M., Ebrahimie E., Mohammadi Dehcheshmeh M., Kent S., Penman J., Hazi A
Es kommt auch im menschlichen Krper vor, unter anderem im Blutplasma
Certain patients naturally resist ICIs, while others show a significant reduction in treatment effectiveness or fail to respond after a set treatment period [117]
6 studies scored three points, and the remaining 4 scored five points, indicating medium and high-quality studies, respectively
